RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
Immunohistochemistry; Immunoblot; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
MiR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis
Year
2016
Function
"The relative levels of senescence-associated miRNAs miR-34a, miR-34b, and miR-34c were significantly higher in type II AECs from IPF patients. Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-Bgal activity (27.8%, 35.1%, And 38.2%, Respectively) relative to control treated cells (8.8%). Targets of miR-34 miRNAs, including E2F1, c-Myc, and cyclin E2, were lower in IPF type II AECs. MiR-34 family of miRNAs regulate senescence in IPF type II AECs."